UBC Human Kinetics – GRIP Laboratory

Research articles

Submitted
Sporer BC, Sheel AW, Taunton, J. Rupert, JL, McKenzie DC. 2006. Inhaled Salbutamol and Doping Control: Effects of Dose on Urine Concentrations. Submitted to Clinical Journal of Sports Medicine.

Published
Witt JD, Guenette JA, Rupert JL, McKenzie DC, Sheel AW. 2007. Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. The Journal of physiology. 584 (Pt 3):1019-28.

Wang P, Koehle MS, Rupert JL. 2007. Common haplotypes in the beta-2 adrenergic receptor gene are not associated with acute mountain sickness susceptibility in Nepalese. High Alt Med Biol. 8(3):206-12.

Koehle MS, Wang P, Guenette JA, Rupert JL. 2006. No association between variants in the ACE and angiotensin II receptor 1 gene and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 metres. High Alt Med Biol. 7(4):281 – 289.

Siddiqui A, Khattra J, Delaney A, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Brown-John M, Chand S, Charters A, Cullum R, Dhalla N, Featherstone R, Hoffman B, Holt R, Lee S, Luis de Algara T, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A, Pandoh P, Rupert JL, Smailus D, Stott J, Tsai M, Wong D, Wu M, Yang G, Zhang I, Hirst M, Jones S, Helgason C, Simpson E, Hoodless P, Marra, M. 2005. A Mouse Atlas of Gene Expression: A public large-scale digital gene expression profiling resource from precisely defined developing C57BL/6J mouse tissues and cells. Proc. Acad. Natl. Sci. (USA) 102(51): 18485–18490.

Rupert JL, Monsalve MV, Kidd KK, Tan C, Hochachka PW, Devine DV. 2003. Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians. Ann. Hum. Genet. 67(5): 426-432.

Monsalve MV, Salzano FM, Rupert JL, Hutz MH, Hill K, Hurtado AM, Hochachka PW, Devine DV. 2003. Methylenetetrahydrofolate reductase (MTHFR) allele frequencies in Amerindians. Ann. Hum. Genet. 67(4): 367-371.

Rupert JL, Kidd K, Norman LE, Monsalve MV, Hochachka PW, Devine DV. 2003. Genetic polymorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American populations. Ann. Hum. Genet. 67(1):17-25.

Rupert JL, Monsalve MV, Devine DV, Hochachka PW. 2000. Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. Ann. Hum. Genet. 64 135–143. (PhD thesis data)

Rupert JL, Devine DV, Monsalve MV, Hochachka PW. 1999. Angiotensin-converting enzyme (ACE) alleles in the Quechua, a high altitude South American native population. Ann. Human Biol. 26 (4) 375-380. (PhD thesis data)

Rupert JL, Devine DV, Monsalve MV, Hochachka PW. 1999. ß-fibrinogen allele frequencies in Peruvian Quechua, a high-altitude native population. Am. J. Phys. Anthro. 109 181-186. (PhD thesis data)

Rupert JL, Brown CJ, Willard HF. 1995. Direct detection of non-random X chromosome inactivation by use of a transcribed polymorphism in the XIST gene. Eur. J. Hum. Genet. 3:333-343

Brown CJ, Miller AP, Carrel L, Rupert JL, Davies KE, Willard HF. 1995. The DXS423E gene in Xp11.21 escapes X chromosome inactivation. Hum. Mol. Genet. 4:251-255.

Brown CJ, Hendrich BD, Rupert JL, Lafrenière RG, Xing Y, Lawrence J, Willard HF. 1992. The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71:527-542.

Brown CJ, Ballabio A, Rupert JL, Lafrenière RG, Grompe M, Tonlorenzi R, Willard HF. 1991. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349:38-44.

Kuliszewski M, Rupert JL, Gold RJM. 1988. The ontogeny of gamma-crystallin mRNAs in Cat Fraser mice. Genet. Res. 52: 45-49.

Rupert JL, Kuliszewski M, Tsui L-C, Breitman ML, Gold RJM. 1988. The murine cataractogenic mutation, Cat Fraser, segregates independently of the gamma crystallin genes. Genet. Res. 51: 23-28. (M.Sc. thesis data)

Peer-reviewed review/conceptual articles

Submitted
Pei Wang, Matthew N. Fedoruk and Jim L. Rupert. 2007. Keeping pace with ACE: are angiotensin converting enzyme inhibitors and angiotensin II receptor blockers potential doping agents? Sports Medicine.

Published
Fedoruk MN and Rupert JL. 2007.  Myostatin inhibition: a potential performance enhancement strategy? Scandinavian Journal of Medicine and Science in Sports. Accepted November 9, 2007. In Press.

Rupert JL and Koehle MS. 2006. The evidence for a genetic basis for altitude-related illness. High Alt. Med. Biol. 7(2) 150-167.

Rupert JL. 2003. The search for genotypes that underlie human performance phenotypes. Comp. Biochem. Physiol. A 136: 191-203.

Hochachka PW, Rupert JL. 2003. Fine Tuning the HIF-1 ‘Global’ O2 sensor for hypobaric hypoxia in Andean high-altitude natives. BioEssays. 25(5) 515-519.

Hochachka PW, Rupert JL. Goldenberg L, Gleave M, Kozlowski P. 2002. Going malignant: the hypoxia connection in prostate cancer. BioEssays 24 749-757.

Rupert JL, Hochachka PW. 2001. Genetic approaches to understanding human adaptation in the Andes. J. Exp. Biol. 204: 3151-3160.

Rupert JL, Hochachka PW. 2001. The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: a review. High Alt. Med. Biol. 2(2): 235-256.

Meeting abstracts / poster presentations

Fedoruk MN and Rupert JL. 2006. Development of a prototype blood-based test for exogenous erythropoietin activity based on transcriptional profiling. 2006 IAAF World Anti-doping Symposium, Lausanne, Switzerland. Epo Project Poster Presentation (PDF).

McGuire A, Querido J, Fedoruk M, P. Wang P, Rupert JL, McKenzie D. 2006. Plasma erythropoietin concentration following normobaric hyperoxia. Canadian Society for Exercise Physiology, Halifax. CSEP Conference Poster Presentation (PDF)

Siddiqui A, Khattra J, Delaney A, Zhao Y, Astell Asano CJ, Babakaiff R, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charters A, Cullum R, Dhalla N, Featherstone R, Hoffman B, Holt R, Kuo BY-L, Lee, S Lee LLC, Leung D, Luis de Algara T, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu A, Pandoh P, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Wong D, Wu M, Xie YY, Yang G, Zhang I, Hirst M, Jones S, Helgason CD, Simpson EM, Hoodless P and Marra M. (2005) A Mouse Atlas of Gene Expression. The Biology of Genomes. Cold Spring Harbor, NY.

Rupert JL, Wu MK, Cullum R, Charters A, Marra M, and Hoodless PA. 2005. Serial analysis of gene expression (SAGE) in the developing mouse lung: Perinatal lung transcriptomes. 35th International Congress of Physiological Sciences/Experimental Biology. San Diego, CA (poster presentation)

Rupert JL, Wu MK, Cullum R, Lee L, Landry A, Khattra J, Helgason CD, Simpson EM, Jones S, Marra M and Hoodless PA. 2004 The Atlas of Gene Expression in Mouse Development. Keystone Symposia: Signalling in Vertebrate Organogenesis. Santa Fe, NM.

Rupert JL, Wu MK, Cullum R, Lee L, Landry A, Khattra J, Helgason CD, Simpson EM, Jones S, Marra M and Hoodless PA. 2004 The Atlas of Gene Expression in Mouse Development: a SAGE Project. The 2nd Annual Canadian Developmental Biology Symposium. Banff, Canada.

Wu M, Rupert JL, Helgason CD, Ruiz de Algara T, Hoodless P. 2003. The Atlas of Gene Expression in Mouse Development Project. The 36th Annual Northwest Regional Developmental Biology Conference. Friday Harbor, Washington.

Wu M, Rupert JL and Hoodless PA. 2003 The Atlas of Gene Expression in Mouse Development (AGEMD) Project. Soc. for Developmental Biology, 62nd Annual Meeting, Boston, MA.

Rupert JL, Kidd K, Norman LE, Monsalve MV, Hochachka PW, Devine DV. 2001. Genetic risk factors for cardiovascular disease and hypertension in high-altitude and low-altitude Native American populations. Am. J. Hum. Genet. 69(4) Suppl.: 421.

Rupert JL, Norman LE, Monsalve MV, Kidd K, Devine DV, Hochachka PW. 2000. Polymorphisms in the renin-angiotensin system in the Quechua, a high-altitude Native population. High Alt. Med. Biol. 1(3): 262

Monsalve MV, Rupert JL, Hutz MH, Hill-Hurtado MH-K, Hochachka PW, Devine DV. 2000. Methylene tetrahydrofolate reductase allele distribution in Amerindians suggests an altitude effect. High Alt. Med. Biol 1(3): 253